Quinolines and derivatives

Medchemexpress LLC Domperidone (R33812) | 57808-66-9 | 99.9% | 200 MG

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Domperidone is an orally active and selective dopamine-2 receptor antagonist. It acts as an antiemetic and a prokinetic agent through its effects on the chemoreceptor trigger zone and motor function of the stomach and small intestine. Unlike Metoclopramide, Domperidone does not cause adverse neurological symptoms due to minimal penetration through the blood-brain barrier, and it is rapidly absorbed after oral administration with few reported side effects.

• Orally active and selective dopamine-2 receptor antagonist.
• Acts as an antiemetic and a prokinetic agent.
• Minimal penetration through the blood-brain barrier.
• Rapidly absorbed after oral administration.
• Few reported side effects.

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Medchemexpress LLC Hydroquinidine | 1435-55-8 | 100.0% | 25 G

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Hydroquinidine, also known as Dihydroquinidine, is a potent ion channel blocker with demonstrated anti-cancer activity against colon, pancreatic, and hepatocellular cancer cells. It is also known to prolong the QT interval and exhibit antiarrhythmic efficacy.

• Potent ion channel blocker
• Demonstrates strong anti-cancer activity on colon, pancreatic, and hepatocellular cancer cells
• Prolongs the QT interval
• Exhibits antiarrhythmic efficacy
• Molecular formula: C20H26N2O2
• Molecular weight: 326.44
• Appearance: White to off-white solid
• For research use only

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Medchemexpress LLC Hydroquinidine | 1435-55-8 | 99.9% | 1 ML

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Hydroquinidine (Dihydroquinidine) is a potent ion channel blocker that demonstrates strong anti-cancer activity against colon, pancreatic, and hepatocellular cancer cells. It also prolongs the QT interval and possesses antiarrhythmic efficacy.

• Potent ion channel blocker
• Exhibits strong anti-cancer activity on colon, pancreatic, and hepatocellular cancer cells
• Prolongs the QT interval
• Possesses antiarrhythmic efficacy
• For research use only

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Medchemexpress LLC Imiquimod maleate | 896106-16-4 | 99.9% | 200 MG

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Imiquimod maleate is an immune response modifier and a selective toll-like receptor 7 (TLR7) agonist. It exhibits antiviral and antitumor effects in vivo. This product is used for research related to external genital, perianal warts, cancer, and COVID-19.

• Immune response modifier
• Selective toll-like receptor 7 (TLR7) agonist
• Exhibits antiviral and antitumor effects in vivo
• Used for research of external genital, perianal warts, cancer, and COVID-19
• Can be used to induce psoriasis models

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Medchemexpress LLC Pazufloxacin (mesylate) | 163680-77-1 | 100.0% | 1 ML

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Pazufloxacin mesylate is an orally active fluoroquinolone antimicrobial agent. It inhibits DNA gyrase with IC50 values of 0.88 μg/mL (E. coli) and 1.9 μg/mL (P. aeruginosa). This agent exhibits broad-spectrum antimicrobial activity with MIC90 values ranging from 0.025 to 100 μg/mL against Gram-positive and Gram-negative bacteria, non-fermenting bacteria, Legionella spp., and anaerobic bacteria. It is indicated for research on systemic infections, lung infections, urinary tract infections, and Legionella pneumonia.

• Orally active fluoroquinolone antimicrobial agent
• Inhibits DNA gyrase
• Exhibits broad-spectrum antimicrobial activity against a variety of bacteria, including gram-positive, gram-negative, non-fermenting, Legionella spp., and anaerobic bacteria
• Indicated for research on systemic infections, lung infections, urinary tract infections, and Legionella pneumonia

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Medchemexpress LLC 8-Hydroxyquinoline | 148-24-3 | 99.95% | 1 G

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8-Hydroxyquinoline (8-Quinolinol) is a lipophilic metal chelator used as a fungicide. It demonstrates an MIC range of 27.56-55.11 μM (4-8 μg/mL) against clinical isolates of *Neisseria gonorrhoeae*. The compound binds to copper, forming complexes that facilitate copper transport into cells. It has also been observed to increase micronucleated polychromatic erythrocytes and cause hair depigmentation in mice. This product is for research use only and is not sold to patients.

• Functions as a lipophilic metal chelator and fungicide
• Exhibits activity against *Neisseria gonorrhoeae*
• Binds to copper to facilitate cellular transport
• Increases micronucleated polychromatic erythrocytes in mice
• May cause hair depigmentation in mice
• Induces cytotoxicity in various cell lines
• Inhibits proteasomal chymotrypsin-like activity
• Reduces inflammation by inhibiting NO production and iNOS expression

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Medchemexpress LLC Azatadine (dimaleate) | 3978-86-7 | 99.85% | 200 MG

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Azatadine dimaleate is an inhibitor of histamine and cholinergic with an IC50 of 6. It also exhibits antiserotonin activity and can be used in research on perennial allergic rhinitis.

• Inhibitor of histamine and cholinergic
• Exhibits antiserotonin activity
• Can be studied in research on perennial allergic rhinitis
• Targets histamine receptor
• Involves GPCR/G protein, immunology/inflammation, and neuronal signaling pathways

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eMolecules​ 7-BROMOQUINOLINE 5G

5000216219 7-BROMOQUINOLINE 5G

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